Link to Publication:
https://www.annalsofoncology.org/article/S0923-7534(19)35638-8/fulltext
Abstract: Many classes of anticancer therapy, including chemotherapeutic agents, hormonal and molecular targeted treatments,
can produce ocular toxicity. Novel agents that target different cellular pathways have been related to a wide spectrum of
ophthalmologic toxicities that can range from mild to severe, and include conjunctivitis, blurred vision, keratitis and optic
neuritis, among others. Special attention has been drawn to the inhibitors of the MEK signaling pathway, due to their sine
qua non ocular toxicity, defined as MEK retinopathy and described as symmetrical bilateral disease that develops in a
time-dependent and dose-dependent manner. In this review, we discuss ophthalmologic toxicities associated with molecular targeted therapies, with particular focus on MEK retinopathy, including its nomenclature, incidence, symptoms
and management.
